Antinociceptive Effect of Pentazocine in Diabetic Rats

Aim: The objective of the current study is to investigate the antinoceptive effect of Pentazocineon streptozotocininduced diabetic rats. Methods: Diabetes mellitus was induced by using streptozotocin, dose of 50mg/kg body weight through lateral tail vein injection. After 48 hours, rat with blood glucose range of 200–300mg were used for experiment. NPH – insulin was given by subcutaneous injection at the doses ranging from 3-5 units daily from 34 th day and continued till 41 st days. The analagesic activity was measured using tail flick method. Result: Graph was plotted between the tail flick response in seconds and days. Conclusion: From the result, it was concluded that the analgesic effect of pentazocine in insulin treated diabetic rat were more than in normal rat, eventhough the glucose levels were almost the same.